This Guidance Note discusses an approach to systematic evidence synthesis in the humanitarian field. Its recommendations apply to the evidence synthesis outputs commissioned by the Humanitarian Evidence Programme, a DFID-funded partnership between Oxfam GB and the Feinstein International Center at Tufts University (FIC). The Programme aims to synthesize research in the humanitarian sector and communicate the findings to policymakers, humanitarian practitioners, and researchers, with the ultimate goal of improving humanitarian policy and practice. This Programme has been funded by UK aid from the UK government; however the views expressed in this guidance note do not necessarily reflect the UK government’s official policies.